Clear Health Centers

Specializing in the Investigation & Treatment
of Underlying Causes of Chronic Conditions


Clear Health Centers

Alzheimer’s Dis-ease

Alzheimer’s disease (AD) is the most common cause of loss of brain function or dementia.

It is an age-related progressive and irreversible neurodegenerative disease resulting in impairments of cognition, memory and behavior.

Available drugs do not offer significant benefit and seem to be ineffective against the progression of this condition.

The Alzheimer’s Disease International Conference, held in Paris, France, showed a mathematical model revealing 7 factors that contribute to the risk worldwide; lack of education (19.1%), smoking (13.9%), lack of physical activity (12.7%), depression (10.6%), high blood pressure at midlife (5.1%), diabetes (2.4%), and midlife obesity (2.0%). 

Amyloid Beta Protein

Alzheimer’s disease is a protein misfolding disease resulting from the accumulation of abnormally folded amyloid-β protein (Aβ) and hyperphosphorylated aggregates of the microtubule-associated (tau) proteins in the brain.

Beta-amyloid plaque, made up of small peptides, is a fragment from the larger amyloid precursor protein (APP) that penetrates through the neuron’s membrane.

Brain neuronal cell survival and death are regulated by organelles in cells called mitochondria which also regulate energy metabolism and cell death pathways.

Numerous studies have established that mitochondrial dysfunction has an early and preponderant role in AD.

Oxidative damage to both mitochondrial and nuclear DNA has been examined in several studies.

This results in diminished production of energy or ATP by mitochondria, resulting in lowered function of brain neurons.

Oxidative nerve cell death in Alzheimer’s disease and the role of neuroprotective antioxidants has been examined.

Poly MVA

Alpha lipoic acid (ALA) is extensively studied as a potent mitochondrial nutrient for improving memory deficit, oxidative stress and mitochondrial dysfunction.

ALA is used to treat peripheral neuropathy, cardiac autonomic neuropathy, insulin resistance in type-II diabetes, retinopathy, cataracts, glaucoma and Alzheimer’s type dementia.

All the data suggest that lipoic acid mineral complex (LAMC or Poly-MVA) has been shown to be far superior to that of ALA.

The complex is extremely safe with practically no side effects and has numerous properties including enhancement of activities of Krebs cycle and mitochondrial respiratory chain enzymes, free radical scavenging properties, and DNA repair.

We strongly believe in its potential for ameliorating some of the deleterious effects of AD.

Naturopathic Medicine

Of course, there is no magic bullet for AD.

Many factors must also be investigated and taken into account.

We refer to the three principles of physical and mental health.

Good nutrition along with complete digestion and assimilation of nutrients. This often requires supplemental support for repair, regeneration and correcting nutrient deficiencies.

The reduction of exposure to chemicals, toxins and heavy metals.

The investigation of underlying low-grade infections (bacteria, viral, mold and parasites) and therapies to remove them from the body.

Mast Cell Activation Syndrome

MCAS is an underlying cause of many, many symptoms, both physical and mental, and because these varied symptoms can manifest in bizarre and unpredictable patterns, and do not present in a typical way to most physicians, this underlying cause is often not considered.

And patients go from one doctor to another to another, trying this medication and that medication, with doctors scratching their heads and thinking idiopathic or atypical, which simply means they don’t understand what the heck is going on.

Mast cells are an integrated part of our natural defense mechanism with its primary function being to send out various chemicals to warn the body of an intruder, whether it’s a foreign organism, a chemical or an unexpected stressor.

They are present in every tissue of the body, but especially in the skin, sinuses, throat, gastrointestinal tract, lungs, and genitourinary tract.

The most abundant chemical that is produced by mast cells is histamine but there are hundreds of others.

In chronic mast cell activation, the person becomes hyper-reactive to chemicals, mold, a virus, and, in some cases, food and even water.  For a number of reasons a person’s mast cells are unable to turn off and remain in a hyperactive state, sometimes even when the insult has been removed.

MCAS is very challenging to diagnose and to treat.  It takes time and dedication on the part of the patient as well as the physician.

Here is a quote from Dr. Lawrence Afrin, MD, a pioneer in the ‘discovery’ of MCAS, from his book, Never Bet Against Occam.’

‘Furthermore, given the complexity of the disease (MCAS), the degree of improvement varies significantly between patients, but the basic principle remains as I’ve stated.

It is easy to become frustrated/disappointed/sad/depressed/despondent when intervention after intervention fails to help, but that doesn’t change the principle, and thus, by definition, the MCAS patient who achieves the therapeutic goal must find some way internally to get past the disappointments of treatment failures.

The key difference in the newly diagnosed MCAS patient’s future life vs. past life is that the patient now has a diagnosis, which can rationally guide therapeutic decision-making.

I have had plenty of patients who have finally found ‘the right drug’ on their 5th or 10th or 15th medication trial.

The biggest frustration at this point is not being able to predict which of these medications is most likely to be helpful in the individual patient.’

It takes time, patience and dedication.

Let us continue.

Mast Cell Activation Triggers

Many people with MCAS are easily triggered by any number of stressors found in their environment and in relationships.

Environmental includes chemicals, mold, fragrances in soaps and cosmetics, EMFs, foods and additives, certain types of clothing, visiting markets or stores where the air is circulating chemicals, hot and cold, sunlight, etc.

Become more aware of triggers and do your best to remove them.

If you have mercury dental amalgams consider replacing them but speak with Dr. Haskell first.

Relationships should be best confined to those who have some understanding about what you are going through with this condition.

I suppose the most important relationship is the one you have with yourself.  Do not be too hard on yourself and develop a state of self-awareness, forgiveness and patience.

Hope with immediate expectations goes a long ways to accompany you along this journey.

Mast Cell Activation Symptoms & Conditions

Mast cells, because of their secretion of diverse chemicals, can produce a wide variety of symptoms and conditions in various parts or tissues of the body and brain.

You can see by the image to the left some, but not all, of the conditions that can arise from these secretions.

Overactive mast cells can be the underlying cause and the objectives of the physician are the following;

  • Take a very detailed history, physical exam and review of symptoms to see if MCAS is possible.
  • Perform the most pertinent tests to differentiate between MCAS and other possibilities such as a Carcinoid tumor.
  • Find the right supplements and/or medications which are appropriate for each client.  There is no set criteria or formula which guides the physician regarding this.
  • Investigate what the possible causes are which have led up to MCAS and, if possible, remove them.
  • Possible causes are the following;
    • Continued exposure to environmental toxins
    • Underlying chronic infection which has not been discovered as yet.
    • Mold exposure
    • Chronic infection due to an infected tooth.
    • Chronic viral infection
    • Compromised pathways of detoxification (liver, gall bladder, colon and kidneys)
    • Gut issues (leaky gut, SIBO, parasites, etc.)

MCAS Lab Testing

There are a few labs which can be run, yet, even if results are negative, they do not necessarily rule out this condition.

We used to think that Tryptase was an equivocal test, but it’s not, partly because it is often negative with confirmed MCAS, but it’s also a very, very difficult blood draw, needing to be kept cold all the time from the blood draw to the analysis, passing through many hands and a long distance.

  • Plasma histamine; the collection process is challenging with histamine being very ‘fragile’ and metabolized quickly. When the blood is collected it must immediately be cooled, like Tryptase.  Centrifuge, spinning the blood into its parts must be done in a ‘cold’ centrifuge.
  • N-methylhistamine 24 hour urine test
  • Prostaglandins PGD2 urine test
  • Serum Chromogranin A
  • Plasma heparin; collection similar to plasma histamine
  • Leukotrienes

The issue with getting accurate results is that usually the person must be experiencing an acute crisis.

Good luck with getting them to the lab when they’re in a crisis.

MCAS Supplements

These supplements help to stabilize mast cells to reduce histamine release.

  • Quercetin
  • D-Hist which has both quercetin and Stinging Nettles
  • Pancreatic enzymes
  • Vitamin C
  • Vitamin B6 in the P5P form
  • Omega III fatty acids
  • N-Acetylcysteine
  • Methylation donors (SAMe, B12, Methyl-folate, riboflavin)
  • Lactobacillus rhamnosus & Bificobacter species
  • DAO enzymes with meals (Umbrellus DAO)

For MCAS it’s also very important to take binders which grab onto toxins in the intestines to prevent the recycling of toxins and metabolic waste back into the body.

With MCAS, a good portion of time during a visit is spent on healing the gut, and one of several binders are often recommended.

  • Organic Activated Coconut Charcoal
  • Tox Ease Binder from Beyond Balance

MCAS Medications

We definitely prefer the more natural approach, but if the decision comes down to trying a prescription, here is a list of what is available for MCAS.

Rule of thumb here is, start with the least expensive.  There is little reason to start with an expensive one since we don’t know which will be the most helpful.

Just to orient you, there are various receptors on cells referred to as H1, H2, H3 and H4 histamine receptors.

Some of these are over the counter, and some are by prescription.

H1 Blockers

  • Diphenhydramine or Benadryl
  • Hydroxyzine
  • Doxypin
  • Cyproheptadine
  • loratadine (Claritin)
  • Fexofenadine
  • Cetirizine (Reactine)
  • Levocetirizine
  • Rupatidine
  • Ketotifen
  • The whole class of tricyclic antidepressants.
  • The whole class of phenothiazine anti-nausea drugs
  • Antipsychotic drug quetiapine

H2 Blockers

  • Famotidine (Pepcid, Pepcid AC)
  • Cimetidine (Tagamet, Tagamet HB)
  • Ranitidine (Zantac)
  • Nizatidine

Leukotriene Inhibitors

  • Montelukast (Singulair)
  • Zafirlukast (Accolate)

Mast Cell Stabilizers

  • Cromolyn
  • Pentosan

Others Include

  • Ivabradine when POTS, tachycardia and heart palpitations are present

Mast Cell Activation: Words of Wisdom

At a recent ISEAI (International Society for Environmentally Acquired Illness), after Dr. Neil Nathan had given a pretty comprehensive list of supplements and prescriptions to use for MCAS, the question was asked, ‘Dr. Neil, which of these do you prefer and use most often?’

He said, ‘The one that works!’

What physician doesn’t want to know what works, but if you’ve read the book by Dr. Lawrence Afrin, then you understand the deep frustrations of any physician treating MCAS.

There is no routine approach with MCAS that always works for everyone.

With MCAS it is important to be patient, to add one thing (supplement, herb, medication) at a time.

We cannot feel rushed thinking that we need to start everything at once.

Most of the work is trial and error, watching how the body responds to each new thing.

It is a partnership between the doctor and the patient, working together, to not only reduce the symptoms of MCAS but to discover and uncover the underlying causes.

Call Us Today to Schedule or Have Questions?


We Believe in Empowering Our Clients Through Education
By Providing Therapies Which Assist Their
Own Innate Capacity To Heal

Contact Information

Clear Health Centers
203 East 800 South
Salt Lake City, UT 84111



Hours of Operation

Monday to Thursday: 9am to 4:30pm
Friday Closed
Closed Weekends and Holidays


Dr. Berkson & Alpha Lipoic Acid

Dr. Berkson, MD, PhD, operates a clinic in Las Cruces, New Mexico, and specializes in all forms of liver disease and complications of diabetes.

With 40 years of experience, his primary approach with recovery is what he terms, the Triple Antioxidant Protocol.

This includes oral and intravenous Alpha Lipoic Acid, selenium and the herb Milk Thistle or Silymarin.

One of many case studies include 79 patients scheduled for liver transplants.  This, of course, is end stage liver failure.

Of these, 75 recovered healthy liver function and did not require the transplant.

In this interview, he explains why this simple and highly effective approach was never accepted by either the hospital/medical system or pharma because it would decrease their income (drugs, surgeries and hospital stays).

Call Us Today To Schedule or 

If You Have Questions






We Believe in Empowering Our Clients Through Education & By Providing Therapies Which Assist Their Own Innate Capacity To Heal




Contact Information

Clear Health Centers
203 East 800 South
Salt Lake City, UT 84111

Monday to Thursday: 9am to 4:30pm
Friday 9am to 1pm
Closed Weekends and Holidays




Call Us Today To Schedule or If You Have Questions


We Believe in Empowering Our Clients Through Education & By Providing Therapies Which Assist Their Own Innate Capacity To Heal

Contact Information

Clear Health Centers
3350 Highland Drive SLC, Utah 84106
866.293.1975 (fax)

Hours of Operation

Monday thru Thurs: 9am to 4:30pm
Friday: 9am to 1pm
Closed Weekends and Holidays